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Practice guidelines should be based on scientific evidence. This ensures that the guidelines reflect the best available knowledge and research, leading to recommendations that are both effective and reliable. Evidence- based practice guidelines help improve patient outcomes by ensuring that clinical decisions are informed by rigorous and up-to-date research findings. * Cost-benefit analysis (A): While important in decision-making, it is not the primary basis for developing practice guidelines. * Computer-generated data (C): This can assist in analyzing data but is not a substitute for evidence- based research. * Utilization review criteria (D): These criteria are more focused on managing healthcare services rather than forming the foundation of clinical guidelines. References * NAHQ Body of Knowledge: Evidence-Based Practice Guidelines * NAHQ CPHQ Exam Preparation Materials: Foundations of Practice Guidelines =========