A. It is best practice to create the database role before creating the schema, to immediately grant ownership on the schema to the created role.

B. When granting privileges to the database role, use the 'APPLICATION' keyword to grant privileges on application objects, enhancing security and control.

C. Populating the configuration table should be done before creating any other objects, as other parts of the application might rely on the configuration during object creation.

D. The setup script should always be designed to be idempotent, meaning it can be executed multiple times without causing errors or unintended side effects. Use 'CREATE ... IF NOT EXISTS' where appropriate.

E. Setup Scripts should be designed in a way that it requires multiple manual interventions during execution.