In Salesforce B2C Commerce, particularly when using the hooks framework, it is possible to register multiple hooks for a single extension point within a single hooks.json file. This feature allows developers to extend or modify the behavior of the base application by specifying different modules that can be called when a particular event or operation occurs. By defining multiple hooks in the hooks.json file, developers can effectively modularize their customizations, making the system more flexible and easier to maintain. Each registered module can be triggered in sequence based on the configuration, providing extensive control over the application's flow and functionalities.