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Comprehensive and Detailed Explanation From Exact Extract: Persistence is a frame averaging function that combines multiple sequential frames to smooth random noise and reduce speckle, particularly effective in stationary or slow-moving structures. According to official Principles and Instrumentation guidelines: "Persistence reduces random noise by averaging multiple frames over time, improving image clarity but potentially reducing temporal resolution." A: Increasing frequency improves resolution but may increase attenuation. B: Sector width affects frame rate. C: Depth affects penetration but not noise reduction.