True , here is an example :

import { LightningElement, wire, track } from 'lwc';
import { refreshApex } from '@salesforce/apex';
import getRecords from '@salesforce/apex/YourController.getRecords';

export default class YourComponent extends LightningElement {
@track data;
wiredResult; // Store the wire result here

// Fetch data with wire
@wire(getRecords)
wiredRecords(result) {
this.wiredResult = result;
if (result.data) {
this.data = result.data;
} else if (result.error) {
// handle error
}
}

// After saving a new record
handleSave() {
// Code to save record...

// Refresh the data
refreshApex(this.wiredResult);
}
}