According to the Nutanix Volumes - Recommendations And Best Practices web search result3, two actions that the administrator should take when designing the Volume Group are:
Distribute workload across multiple virtual disks: Use multiple disks rather than a single large disk for an application. Consider using a minimum of one disk per Nutanix node to distribute the workload across all nodes in a cluster. Multiple disks per Nutanix node may also improve an application's performance. For performance-intensive environments, we recommend using between four and eight disks per CVM for a given workload.
Enable RSS (Receive Side Scaling): Receive-side scaling (RSS) allows the system to use multiple CPUs for network activity. With RSS enabled, multiple CPU cores process network traffic, preventing a single CPU core from becoming a bottleneck. Enabling RSS within hosts can be beneficial for heavy iSCSI workloads. For VMs running in ESXi environments, RSS requires VMXNET3 VNICs. For Hyper-V environments, enable VMQ to take full advantage of Virtual RSS.