Yes, it is possible to remove the approval requirement for an application in IdentityNow by editing the access profile and unchecking the 'Required Approval' box. This configuration change would eliminate the need for a manager or other approver to review access requests, allowing users to be granted access without requiring approval.
Key Reference from SailPoint Documentation:
Access Profile Configuration: Access profiles can be configured to require or not require approval for access requests, and this option can be modified directly in the profile settings.