Explanation/Reference:
Explanation:
Volumes that are candidates for deduplication must conform to the following requirements:
Must not be a system or boot volume. Deduplication is not supported on operating system volumes.

(Thus NOT C:)
Can be partitioned as a master boot record (MBR) or a GUID Partition Table (GPT), and must be

formatted using the NTFS file system. (Thus NOT D:)
Can reside on shared storage, such as storage that uses a Fibre Channel or an SAS array, or when an

iSCSI SAN and Windows Failover Clustering is fully supported.
If you're using Windows Server 2012, don't deduplicate Cluster Shared Volumes (CSVs). You can

access data if a deduplication-enabled volume is converted to a CSV, but you cannot continue to process files for deduplication on Windows Server 2012.
Do not rely on the Microsoft Resilient File System (ReFS). (Thus NOT F:)

Can't be larger than 64 TB in size.

Must be exposed to the operating system as non-removable drives. Remotely-mapped drives are not

supported.
References: https://technet.microsoft.com/en-us/library/hh831700(v=ws.11).aspx