Explanation/Reference:
From Scenario:
The antivirus application must not scan SharePoint directories.
Folders that may have to be excluded from antivirus scanning in SharePoint SharePoint Foundation 2013 You may have to configure your antivirus software to exclude the following folders and subfolders from antivirus scanning:
Drive:\Program Files\Common Files\Microsoft Shared\Web Server Extensions


If you do not want to exclude the whole Web Server Extensions folder from antivirus scanning, you

SharePoint Server 2013
You may have to configure the antivirus software to exclude the Drive:\Program Files\Microsoft Office Servers folder from antivirus scanning for SharePoint Server 2013. If you do not want to exclude the whole Microsoft Office Servers folder from antivirus scanning, you can exclude only the following folders:
Drive:\Program Files\Microsoft Office Servers\15.0\Data

(This folder is used for the indexing process. If the index files are configured to be located in a different

folder, you also have to exclude that location.)
Drive:\Program Files\Microsoft Office Servers\15.0\Logs

Drive:\Program Files\Microsoft Office Servers\15.0\Bin

Drive:\Program Files\Microsoft Office Servers\15.0\Synchronization Service

Any location in which you decided to store the disk-based binary large object (BLOB) cache (for

example, C:\Blobcache).
Note If you have SharePoint Server 2013, these folders should be excluded in addition to the folders that are listed in the "SharePoint Foundation 2013" section.
Reference:https://support.microsoft.com/en-us/kb/952167