In Hyperledger Fabric, when executing queries on the ledger, the difference between simple keys and composite keys is significant. Simple keys consist of a single attribute and are straightforward in their use for querying. In contrast, composite keys are formed by combining multiple attributes into a single key, allowing for more complex queries based on multiple fields. Composite keys enable richer, more flexible query capabilities that can facilitate refined searches and analyses within the ledger. This capability is particularly useful in scenarios where a single attribute is not sufficient to uniquely identify ledger entries or when queries need to filter based on multiple criteria.