The VRFY and EXPN commands can be used to enumerate user accounts on an SMTP server, as they are used to verify the existence of users or mailing lists. VRFY (verify) asks the server to confirm that a given user name or address is valid. EXPN (expand) asks the server to expand a mailing list into its individual members.
These commands can be used by a penetration tester to identify valid user names or e-mail addresses on the target SMTP server.