Folder and File Exclusion/Inclusion
In Citrix Profile Management, there is a GPO that can be specifically configured to block folders and files from profile synchronization.
AppData\LocalLow: the files under this folder are almost low importance, and this folder is excluded by default in Citrix Profile Management INI file.
AppData\Local: many apps writes their application data to AppData\Local, such as temporary data, cache files and other junk that does not and should not persist, causing this folder bloat. Also some files under AppData\Local, such as DAT file or INI files which contain all the user important personalization settings. If you exclude the whole folder AppData\Local to reduce the profile size and synchronization speed, you may also lose some app settings when you roam between different clients. At this time, you should take a close look and figure out what exactly the application is writing and whether or not it really needs to persist, then include the necessary ones, exclude the unnecessary ones.
AppData\Roaming: the files under this folder are generally treated to be copied back to user store. It is recommended to allow this folder to retain the application settings, and there are several folders under AppData\Roaming that are excluded by default in INI file. You can add those folders to be excluded from sync which you do not wish to include.
Except the AppData folder, other folders and files under the profile can also be excluded/included according to your requirement. With a help of a suitable configuration the app can be made to persist without synchronising or roaming the entire directory. This would ensure the profile is small. And there are some default exclusions defined in Citrix Profile Management INI file.
https://support.citrix.com/article/CTX224498