Cloud deployments differ from on-prem deployments primarily in terms of cost structure, scalability, and management. Cloud deployments typically have lower upfront costs because they utilize a pay-as-you-go model where the organization pays for the resources it consumes, rather than investing in the physical infrastructure and maintenance associated with on-premises deployments. This model also allows for greater scalability, as resources can be adjusted based on demand without the need for purchasing additional hardware. Furthermore, cloud deployments are managed by the service provider, reducing the burden on the organization's IT staff.