BPS-Pharmacotherapy Exam Dumps | A pharmacotherapy specialist is conducting a pharmacokinetic study of a drug. The pharmacokinetic profile

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Question 18/61

A pharmacotherapy specialist is conducting a pharmacokinetic study of a drug. The pharmacokinetic profile of this drug is best described by a one-compartment model with a mean elimination rate constant of 0.173/h. The standard curve for the assay to be used covers the range of 5-40mcg/mL. Samples are collected shortly after single intravenous bolus drug administration, and at 4 and 8 hours after dosing. Preliminary analysis shows that the 4-hour sample concentration is 25 mcg/mL. In this situation, which of the following statements is correct?

A. All plasma concentrations are probably within the range of the standard curve and can be reliably measured.

B. Both the initial and 8-hour concentration points are probably outside the range of the standard curve but can be reliably quantitated by extrapolating the curve to higher and lower points.

C. Both the initial and 8-hour concentration points are probably outside the range of the standard curve and cannot be reliably measured without diluting the samples.

D. The initial plasma concentration is probably outside the range of the standard curve' it may be possible to dilute the sample and re-assay.

Question 18/61

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