NAPLEX Exam Dumps | Which of these cardiovascular drug classes is most associated with tachyphylaxis?

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NABP
North American Pharmacist Licensure Examination
NABP.NAPLEX.v2022-05-25.q74
Question 58

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Question 58/74

Which of these cardiovascular drug classes is most associated with tachyphylaxis?

A. ACE inhibitors

B. Angiotensin-receptor blockers

C. Direct renin inhibitors

D. Calcium channel blockers

E. Nitrates

Correct Answer: E

Explanation
Tachyphylaxis is the phenomenon where a patient experiences a rapid form of drug tolerance. Nitrates exhibit this property. It means that the patient becomes tolerance very quickly and so repeat doses become more and more ineffective. To overcome the problem of tachyphyaxis, then, sufficient time must elapse between doses.

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