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Question 25/54
Which of these medicines is well-known to cause a positive direct Coombs test?
Correct Answer: A
Explanation
The direct Coombs test is used to test for autoimmune hemolyticanemia - a condition in which the body attacks red blood cells, leading to anemia. Some drugs can cause a positive direct Coombs test - methyldopa being one of the most well-known (via IgG-mediated type II hypersensitivity reaction). Other drugs that can cause this effect include quinidine (IgM-mediated activation) and penicillins (at very high doses).
The direct Coombs test is used to test for autoimmune hemolyticanemia - a condition in which the body attacks red blood cells, leading to anemia. Some drugs can cause a positive direct Coombs test - methyldopa being one of the most well-known (via IgG-mediated type II hypersensitivity reaction). Other drugs that can cause this effect include quinidine (IgM-mediated activation) and penicillins (at very high doses).
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